What is the difference between Loss on drying(LOD) and moisture content (MC)?
Given below are the differences between Loss on Drying (LOD) and Moisture Content (MC) in the context of pharmacy:
Aspect |
Loss
on Drying (LOD) |
Moisture
Content (MC) |
Definition |
The
measurement of the weight loss of a substance upon drying |
The
measurement of the water content within a substance |
Purpose |
Determines
the volatile matter in a sample |
Quantifies
the total water content in a sample |
Method |
Involves
heating the sample to evaporate moisture |
Utilizes
a variety of techniques to assess water content |
Measurement |
Reported
as a percentage of the initial sample weight |
Reported
as a percentage or absolute value of the sample weight |
Applicability |
Primarily
used for substances that are prone to volatilize on drying |
Applicable
to a wide range of substances, including liquids, solids, and semi-solids |
Sensitivity |
Sensitive
to both volatile and non-volatile components of the sample |
Sensitive
to all forms of water, including bound and free water |
Regulatory
Consideration |
Some
pharmacopeias define specific limits for LOD |
Some
pharmacopeias define limits for MC |
Examples |
Determining
water content in excipients, active pharmaceutical ingredients (APIs), and
herbal extracts |
Measuring
moisture content in tablets, ointments, and creams |
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