Meropenem resistance in bacteria

There are various genes that are associated with meropenem resistance in bacteria. Some of the most common resistance genes include:

1. Klebsiella pneumoniae carbapenemase (KPC): This gene is found in Klebsiella pneumoniae and other Enterobacteriaceae family of bacteria. KPC-producing bacteria are resistant to multiple antibiotics, including carbapenems such as meropenem.

2. New Delhi metallo-beta-lactamase (NDM): This gene is found in Enterobacteriaceae and Pseudomonas aeruginosa. NDM-producing bacteria are resistant to multiple antibiotics, including carbapenems such as meropenem.

3. Verona integron-encoded metallo-beta-lactamase (VIM): This gene is found in Pseudomonas aeruginosa and other gram-negative bacteria. VIM-producing bacteria are resistant to multiple antibiotics, including carbapenems such as meropenem.

4. Imipenemase (IMP): This gene is found in Enterobacteriaceae and Pseudomonas aeruginosa. IMP-producing bacteria are resistant to multiple antibiotics, including carbapenems such as meropenem.

These resistance genes can be acquired through horizontal gene transfer, and their spread is a growing concern in healthcare settings. The identification of resistance genes can help guide treatment decisions and prevent the spread of resistant bacteria.