Any drug molecule whether water soluble or not can be made sustain release dosage form by using suitable excipients-clarify this by example needed.

Yes, it is possible to formulate drug molecules into sustained-release dosage forms using suitable excipients. Sustained-release formulations are designed to release the drug slowly and steadily over an extended period, which can help improve patient compliance and reduce the frequency of dosing.

There are several types of excipients that can be used to create sustained-release formulations, including polymers, lipids, and surfactants. These excipients can control the rate and extent of drug release by various mechanisms such as diffusion, erosion, and swelling.

For example, hydrophilic polymers such as hydroxypropyl methylcellulose (HPMC) and sodium carboxymethylcellulose (CMC) can be used to create sustained-release tablets or capsules. These polymers form a gel-like matrix when exposed to water, which slows down the release of the drug by diffusion through the matrix.

Similarly, hydrophobic polymers such as ethylcellulose and poly(lactic-co-glycolic acid) (PLGA) can be used to create sustained-release microspheres or implants. These polymers form a barrier around the drug, which controls the release by erosion or degradation of the polymer.

Another example is the use of lipid-based excipients such as solid lipids or lipid matrices to create sustained-release formulations. These excipients can form a diffusion barrier around the drug or alter the permeability of the membrane to control drug release.

Overall, the choice of excipients and the formulation strategy depends on the physicochemical properties of the drug molecule and the desired release profile. Sustained-release formulations can provide numerous benefits to patients, including improved therapeutic efficacy, reduced side effects, and improved patient compliance.