Suppose, you are asked to prepare 0.2% w/w salbutamol preparation, what will be your formula and manufacturing procedure to obtain this formulation?

To prepare a 0.2% w/w salbutamol preparation, we will need to follow a specific formula and manufacturing procedure. Here is one possible way to prepare this formulation:

Formula:

1.   Salbutamol: 0.2 g

2.   Excipients (such as propellant, stabilizers, and co-solvents): q.s. to 100 g

Manufacturing Procedure:

1.   Weigh out 0.2 g of salbutamol using a balance that is accurate to at least 0.001 g.

2.   Place the salbutamol into a clean, dry mixing vessel.

3.   Add the excipients, such as propellant, stabilizers, and co-solvents, to the mixing vessel, using enough to make a total of 100 g of the preparation. The exact amounts of each excipient will depend on the specific formulation being used.

4.   Mix the salbutamol and excipients thoroughly using a suitable mixing method, such as vortexing, shaking, or stirring.

5.   Transfer the mixture into a clean, dry aerosol canister that has been fitted with a valve and actuator.

6.   Seal the canister and pressurize it with the propellant to the desired pressure, following the manufacturer's instructions.

7.   Check the weight of the canister to ensure that it contains the correct amount of preparation.

8.   Test the canister to ensure that it delivers the correct amount of medication per actuation, according to the manufacturer's instructions and any applicable regulatory requirements.