Thiazide diuretics
Distal convoluted tubule (DCT)
Thiazide
diuretics
These
are most commonly prescribed drugs. But they also have weak diuretic effect. These
drugs give their effect by working in distal convoluted tubule (Dct) where they
reduce the absorption of Sodium Chloride by inhibiting Na+ Cl- Cotransporter.
Now,
In DCT there. Sodium Chloride Cotransporter through which Sodium chloride get
in the cell from lumun.
Then,
sodium get transported to the blood via Sodium Potassium ATPase. While
Chloride Chloride diffuses out on the
other side via channel. when thiazide diuretics introduced they inhibit the Na+Cl-
cotansporter which decreased Na+ Cl- reabsorption and
increased urine output.
Drug:
(a)Benzothiadiazines
Hydrochlorothiazide,Benzthiazide,Hydroflumethiazide,
Bendroflumethiazide
(b) Thiazide like
Chlorthalidone, Metolazone,Indapamide, Clopamide
Uses -
·
used
as diuretics and as an antihypertensive
·
Used
to treat edema.
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