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Thiazide diuretics

 

Distal convoluted tubule (DCT)

Thiazide diuretics


These are most commonly prescribed drugs. But they also have weak diuretic effect. These drugs give their effect by working in distal convoluted tubule (Dct) where they reduce the absorption of Sodium Chloride by inhibiting Na+ Cl-  Cotransporter.

Now, In DCT there. Sodium Chloride Cotransporter through which Sodium chloride get in the cell from lumun.

Then, sodium get transported to the blood via Sodium Potassium ATPase. While Chloride  Chloride diffuses out on the other side via channel. when thiazide diuretics introduced they inhibit the Na+Cl- cotansporter which decreased Na+ Cl- reabsorption and increased urine output.

Drug:

(a)Benzothiadiazines

Hydrochlorothiazide,Benzthiazide,Hydroflumethiazide,

Bendroflumethiazide

(b) Thiazide like

Chlorthalidone, Metolazone,Indapamide, Clopamide


Uses -

·       used as diuretics and as an antihypertensive

·       Used to treat edema.

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