Loop of henle

 

Loop of henle

This drug gives great derivative effect.This drugs give their effect by working in loop of henle.

 

Macanism Of Action:

It works in ascending Limb of loop of henle.Here sodium-potassium chloride cotransporter is present.which enter Na⁺, k⁺, Cl- into cells through which Na⁺ transported into blood via Na⁺/K⁺ ATPase and Cl^- via cloride channel.

Now, K+ get back into lumen through K⁺ channel.Due to K⁺ ions in lumen increases,positivety increases in lumen results secretion of mg²⁺,Ca²⁺ into blood through paracellular reabsorbtion.About 25℅ of Na⁺,Cl^- get reabsorbed into blood in this.

when loop diuretics introducid  they inhibits Na⁺ K⁺ Cl^- cotransporter and reduce the reabsorption of Na⁺ + Cl^-.

•These diuretics also inhibit the reabsorption of Mg²⁺ and Ca²⁺

Drug: Sulphamoyl derivatives: Furosemide, Bumetanide, Torasemide .