How glucose levels are control in the cells?

 How glucose levels are control in the cells?

 

Hexokines and Glucokinase are two enzymes that both convert glucose into glucose-6-phosphate. But the Km of Glucokinase is higher than the Hexokines. That means the affinity of Glucokinase is lower than that of Hexokines. Therefore, when the concentration of glucose in the cell is low, Glucokinase Cannot convert converts glucose to glucose 6 phosphate.

And since the Km of Hexokines is low, Hexokines can convert glucose into glucose 6 phosphate even if the concentration of glucose is low. On the other hand, the V_max of Glucokinase is higher than Hexokines. As a result, when there is more glucose in the cell, Glucokinase can convert glucose into glucose 6 phosphate but Hexokines cannot. Thus, these two enzymes control the glucose level in the cells.