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Why take gastric medicine after taking pain killer?/ How does NSAID cause peptic ulcer?


Gastric acid secretion is stimulated by acetylcholine, histamine, and gastrin . The receptor-mediated binding of acetylcholine, histamine, or gastrin results in the activation of protein kinases, which in turn stimulates the H+/K+-adenosine triphosphatase (ATPase) proton pump to secrete hydrogen ions in exchange for K+ into the lumen of the stomach. On the other hand Prostaglandin E, produced by the gastric mucosa, inhibits secretion of acid and stimulates secretion of mucus and bicarbonate. When the NASID drug is used, it binds to the prostaglandin receptor to inhibit prostaglandin function.  As a result, acid secretion increases.If this process continues for a long time, it can lead to peptic ulcer. So after taking NASID drug you have to take PPI drug. Which binds with H2 receptors, and it reduce the secretion of gastric acid.


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