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why antacids are given in combination?


Antacids are used commonly in combination for three reasons:such us:

 1. To combine fast and slow-reacting antacids in order to obtain a product with a rapid onset and relatively sustained action.

E.g. Mg(OH)2 (having fast onset of action and short duration of action) and Al(OH)3 (having slow onset of action and prolonged duration of action) are used together in most of the antacid mixtures.

2. To use one component to antagonize one or more side effects of another component.

E.g. mixture of Mg(OH)2 (having laxative effect) and Al(OH)3/CaCO3 (having constipative effect) is done to balance the laxative and constipative effects.

3. To lower the dose of each component and minimize the possibility of certain adverse effects.

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