Barbiturates and Benzodiazepines
Barbiturates |
Benzodiazepines |
1. It has more pronounced
CNS depressant action. |
It has less pronounced CNS
depressant action. |
2. Barbiturates depress
general neurons also. |
Benzodiazepines not depress
general neurons. |
3. It has less therapeutic
index |
High therapeutic index. |
4. Not so safe |
More safer than Barbiturates |
5. Acute overdose causes
serious cardio respiratory depression, coma & death |
Relatively safer in
overdose in comparison with barbiturates. |
6. Marked hangover |
Less hangover |
7. Rapid developing
tolerance |
Slowly developing tolerance
|
8. Addiction liability is
greater |
Less addiction liability |
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