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Barbiturates and Benzodiazepines

 

Barbiturates

Benzodiazepines

1. It has more pronounced CNS depressant action.

It has less pronounced CNS depressant action.

2. Barbiturates depress general neurons also.

Benzodiazepines not depress general neurons.

3. It has less therapeutic index

High therapeutic index.

4. Not so safe

More safer than Barbiturates

5. Acute overdose causes serious cardio respiratory depression, coma & death

Relatively safer in overdose in comparison with barbiturates.

6. Marked hangover

Less hangover

7. Rapid developing tolerance

Slowly developing tolerance

8. Addiction liability is greater

Less addiction liability

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