ABSTRACT: The oral route of drug delivery is typically considered the preferred and most patient-convenient means of drug administration. With many drugs the basic Goal of therapy is to achieve a steady-state blood or tissue level that is therapeutically effective and nontoxic for an extended period of time. Sustain release system are considered a wiser approach for the drugs with short half-lives and which require repeated dosing, they are easy to formulate and are irrespective of absorption process from gastrointestinal tract after oral administration. The basic objective of these dosage forms is to optimize the delivery of medications so as to achieve a measure of control on therapeutic effect in the face of uncertain fluctuations in the in vivo environment in which drug release takes place. The advances in the formulation technology of modified release dosage form with sustained release oral dosage form has been widely accepted approach as compared to conventional immediate release...
Gas Chromatography (GC or GLC) is a commonly used analytic technique in many research and industrial laboratories for quality control as well as identification and quantitation of compounds in a mixture. GC is also a frequently used technique in many environmental and forensic laboratories because it allows for the detection of very small quantities. A broad variety of samples can be analyzed as long as the compounds are sufficiently thermally stable and reasonably volatile. How does gas chromatography work? Like for all other chromatographic techniques, a mobile and a stationary phase are required for this technique. The mobile phase (=carrier gas) is comprised of an inert gas i.e., helium, argon, or nitrogen. The stationary phase consists of a packed column in which the packing or solid support itself acts as stationary phase, or is coated with the liquid stationary phase (=high boiling polymer). Most analytical gas chromatographs use capillary columns, where the stationary phase coa...
WHAT IS DRUG DELIVERY SYSTEMS? Drug delivery systems refer to the technology utilized to present the drug to the desired body site for drug release and absorption. What is a sustained release Drug Delivery systems? Answer: Drug Delivery systems that are designed to achieve prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose.” Basic goal of the therapy to achieve steady state blood level that is therapeutically effective & non toxic for an extended period of time. What is the Characteristics of Drugs which have to avoid to prepare sustaine release drug dosage form? Answer: 1. Those which are absorbed and excreted rapidly; short biological half life(<1 hr). Ex- Penicillin G , Furosemide. 2. Those with long biologic half life(>12 hrs). Ex- Diazepam, Phenytoin. 3. For those which require large doses...
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